WormFlux: mechanistic analysis of C. elegans metabolism

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Use wild characters " ? " and " * " for efficient search:

? : A single character. E.g., trehalose?phosphatase covers both trehalose phosphatase and trehalose-phosphatase, of which, only the latter fits the nomenclature used in this database.
* : Any number of characters. E.g.,tre-* brings all genes from trehalase family; coenzyme*A covers coenzyme A, coenzyme-A, and coenzymeA.

Network Biomass WormPaths

PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal

Metabolite Overview

Abbreviation .....................................................	:	hista
Name .....................................................	:	Histamine, etc.1H-Imidazole-4-ethanamine, 2-(4-Imidazolyl)ethylamine
Model ID .....................................................	:	C00388
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C00388
Formula .....................................................	:	C5H10N3
Charge .....................................................	:	+1
Localization .....................................................	:	Cytosol, Extracellular
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	hista
Other associations .....................................................	:	See reaction table below.

In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Histidine degradation (c,e)

iCEL1314

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Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RC01167Name: L-histidine carboxy-lyase (histamine-forming) Type: Regular Location: Cytosol KEGG ID: R01167 click to see details on this item	4.1.1.28Name: aromatic-L-amino-acid decarboxylase Other names: DOPA decarboxylase, tryptophan decarboxylase, hydroxytryptophan decarboxylase, L-DOPA decarboxylase, aromatic amino acid decarboxylase, 5-hydroxytryptophan decarboxylase, aromatic-L-amino-acid carboxy-lyase (tryptamine-forming) click to see details on this item	[c] : hName: H+ Formula: H Charge: 1 click to see details on this item + his-LName: L-Histidine Formula: C6H9N3O2 Charge: 0 click to see details on this item		co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item + histaName: Histamine Formula: C5H10N3 Charge: 1 click to see details on this item	bas-1 \| hdl-1 \| tdc-1	Histidine degradation
TCE0464Name: Histamine transport Type: Transport Location: Cytosol, Extracellular KEGG ID: NA click to see details on this item	Not applicable	histaName: Histamine Formula: C5H10N3 Charge: 1 click to see details on this item[e]		histaName: Histamine Formula: C5H10N3 Charge: 1 click to see details on this item[c]	Not determined	Transport
EX00388Name: Histamine exchange Type: Exchange Location: Extracellular KEGG ID: NA click to see details on this item	Not applicable	histaName: Histamine Formula: C5H10N3 Charge: 1 click to see details on this item[e]			Not applicable	Exchange with the environment

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