Network Biomass WormPaths

FBAFlux Balance Analysis PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network

Pathway Overview

Name .....................................................	:	TCA cycle
Related pathway (?) The pathway found in other databases to which this pathway is related. .....................................................	:	ERROR
Number of reactions .....................................................	:	15
In WormPaths (?) If the pathway is available as a WormPaths map you will find the name and link of map here. .....................................................	:	TCA cycle

External links

Reactions (?) Click to see these reactions in the related KEGG pathway (only enzymes that are represented in kegg are highlighted).

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RM00351Name: acetyl-CoA:oxaloacetate C-acetyltransferase (thioester-hydrolysing) Type: Regular Location: Mitochondria KEGG ID: R00351 click to see details on this item	2.3.3.1Name: citrate (Si)-synthase Other names: (R)-citric synthase, citrate oxaloacetate-lyase [(pro-3S)-CH2COO-->acetyl-CoA] click to see details on this item	[m] : accoaName: Acetyl-CoA Formula: C23H34N7O17P3S Charge: -4 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + oaaName: Oxaloacetate Formula: C4H2O5 Charge: -2 click to see details on this item		citName: Citrate Formula: C6H5O7 Charge: -3 click to see details on this item + coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	cts-1	TCA cycle
RC00352Name: acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating] Type: Regular Location: Cytosol KEGG ID: R00352 click to see details on this item	2.3.3.8Name: ATP citrate synthase Other names: ATP-citric lyase, ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-->acetyl-CoA] (ATP-dephosphorylating), acetyl-CoA:oxaloacetate acetyltransferase (isomerizing, ADP-phosphorylating), adenosine triphosphate citrate lyase, citrate cleavage enzyme, citrate-ATP lyase, citric cleavage enzyme, ATP citrate (pro-S)-lyase click to see details on this item	[c] : atpName: ATP Formula: C10H12N5O13P3 Charge: -4 click to see details on this item + citName: Citrate Formula: C6H5O7 Charge: -3 click to see details on this item + coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item		adpName: ADP Formula: C10H12N5O10P2 Charge: -3 click to see details on this item + piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item + accoaName: Acetyl-CoA Formula: C23H34N7O17P3S Charge: -4 click to see details on this item + oaaName: Oxaloacetate Formula: C4H2O5 Charge: -2 click to see details on this item	acly-2 | acly-1	TCA cycle
RCC0001Name: citrate hydro-lyase (cis-aconitate-forming) Type: Regular Location: Cytosol KEGG ID: R01325;R01900 click to see details on this item	4.2.1.3Name: aconitate hydratase Other names: cis-aconitase, aconitase, AcnB, 2-methylaconitate hydratase, citrate(isocitrate) hydro-lyase click to see details on this item	[c] : citName: Citrate Formula: C6H5O7 Charge: -3 click to see details on this item		icitName: Isocitrate Formula: C6H5O7 Charge: -3 click to see details on this item	aco-1	TCA cycle
RMC0001Name: isocitrate hydro-lyase (cis-aconitate-forming) Type: Regular Location: Mitochondria KEGG ID: R01325;R01900 click to see details on this item	4.2.1.3Name: aconitate hydratase Other names: cis-aconitase, aconitase, AcnB, 2-methylaconitate hydratase, citrate(isocitrate) hydro-lyase click to see details on this item	[m] : citName: Citrate Formula: C6H5O7 Charge: -3 click to see details on this item		icitName: Isocitrate Formula: C6H5O7 Charge: -3 click to see details on this item	aco-2	TCA cycle
RC00267Name: Isocitrate:NADP+ oxidoreductase Type: Regular Location: Cytosol KEGG ID: R00267 click to see details on this item	1.1.1.42Name: isocitrate dehydrogenase (NADP+) Other names: oxalosuccinate decarboxylase, oxalsuccinic decarboxylase, isocitrate (NADP) dehydrogenase, isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase, NADP-specific isocitrate dehydrogenase, NADP-linked isocitrate dehydrogenase, NADP-dependent isocitrate dehydrogenase, NADP isocitric dehydrogenase, isocitrate dehydrogenase (NADP-dependent), NADP-dependent isocitric dehydrogenase, triphosphopyridine nucleotide-linked isocitrate dehydrogenase-oxalosuccinate carboxylase, NADP+-linked isocitrate dehydrogenase, IDH (ambiguous), dual-cofactor-specific isocitrate dehydrogenase, NADP+-ICDH, NADP+-IDH, IDP, IDP1, IDP2, IDP3 click to see details on this item	[c] : icitName: Isocitrate Formula: C6H5O7 Charge: -3 click to see details on this item + nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item		akgName: 2-Oxoglutarate Formula: C5H4O5 Charge: -2 click to see details on this item + co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item	idh-1	TCA cycle
RM00267Name: Isocitrate:NADP+ oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R00267 click to see details on this item	1.1.1.42Name: isocitrate dehydrogenase (NADP+) Other names: oxalosuccinate decarboxylase, oxalsuccinic decarboxylase, isocitrate (NADP) dehydrogenase, isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase, NADP-specific isocitrate dehydrogenase, NADP-linked isocitrate dehydrogenase, NADP-dependent isocitrate dehydrogenase, NADP isocitric dehydrogenase, isocitrate dehydrogenase (NADP-dependent), NADP-dependent isocitric dehydrogenase, triphosphopyridine nucleotide-linked isocitrate dehydrogenase-oxalosuccinate carboxylase, NADP+-linked isocitrate dehydrogenase, IDH (ambiguous), dual-cofactor-specific isocitrate dehydrogenase, NADP+-ICDH, NADP+-IDH, IDP, IDP1, IDP2, IDP3 click to see details on this item	[m] : icitName: Isocitrate Formula: C6H5O7 Charge: -3 click to see details on this item + nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item		akgName: 2-Oxoglutarate Formula: C5H4O5 Charge: -2 click to see details on this item + co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item	idh-1 | idh-2	TCA cycle
RM00709Name: Isocitrate:NAD+ oxidoreductase (decarboxylating) Type: Regular Location: Mitochondria KEGG ID: R00709 click to see details on this item	1.1.1.41Name: isocitrate dehydrogenase (NAD+) Other names: isocitric dehydrogenase, beta-ketoglutaric-isocitric carboxylase, isocitric acid dehydrogenase, NAD dependent isocitrate dehydrogenase, NAD isocitrate dehydrogenase, NAD-linked isocitrate dehydrogenase, NAD-specific isocitrate dehydrogenase, NAD isocitric dehydrogenase, isocitrate dehydrogenase (NAD), IDH (ambiguous), nicotinamide adenine dinucleotide isocitrate dehydrogenase click to see details on this item	[m] : icitName: Isocitrate Formula: C6H5O7 Charge: -3 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item		akgName: 2-Oxoglutarate Formula: C5H4O5 Charge: -2 click to see details on this item + co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item	idha-1 & idhb-1 & (idhg-1 | idhg-2)	TCA cycle
RMC0003Name: 2-oxoglutarate dehydrogenase Type: Regular Location: Mitochondria KEGG ID: R00621;R03316;R02570;R07618 click to see details on this item	1.2.4.2Name: oxoglutarate dehydrogenase (succinyl-transferring) Other names: 2-ketoglutarate dehydrogenase, 2-oxoglutarate dehydrogenase, 2-oxoglutarate: lipoate oxidoreductase, 2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating), alpha-ketoglutarate dehydrogenase, alphaketoglutaric acid dehydrogenase, alpha-ketoglutaric dehydrogenase, alpha-oxoglutarate dehydrogenase, AKGDH, OGDC, ketoglutaric dehydrogenase, oxoglutarate decarboxylase, oxoglutarate dehydrogenase, oxoglutarate dehydrogenase (lipoamide) click to see details on this item 2.3.1.61Name: dihydrolipoyllysine-residue succinyltransferase Other names: dihydrolipoamide S-succinyltransferase, dihydrolipoamide succinyltransferase, dihydrolipoic transsuccinylase, dihydrolipolyl transsuccinylase, dihydrolipoyl transsuccinylase, lipoate succinyltransferase (Escherichia coli), lipoic transsuccinylase, lipoyl transsuccinylase, succinyl-CoA:dihydrolipoamide S-succinyltransferase, succinyl-CoA:dihydrolipoate S-succinyltransferase, enzyme-dihydrolipoyllysine:succinyl-CoA S-succinyltransferase click to see details on this item 1.8.1.4Name: dihydrolipoyl dehydrogenase Other names: LDP-Glc, LDP-Val, dehydrolipoate dehydrogenase, diaphorase, dihydrolipoamide dehydrogenase, dihydrolipoamide:NAD+ oxidoreductase, dihydrolipoic dehydrogenase, dihydrothioctic dehydrogenase, lipoamide dehydrogenase (NADH), lipoamide oxidoreductase (NADH), lipoamide reductase, lipoamide reductase (NADH), lipoate dehydrogenase, lipoic acid dehydrogenase, lipoyl dehydrogenase, protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase click to see details on this item	[m] : akgName: 2-Oxoglutarate Formula: C5H4O5 Charge: -2 click to see details on this item + coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item		co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item + succoaName: Succinyl-CoA Formula: C25H35N7O19P3S Charge: -5 click to see details on this item	(ogdh-1 & ogdh-2) & dlst-1 & dld-1	TCA cycle
RM00432Name: Succinate:CoA ligase (GDP-forming) Type: Regular Location: Mitochondria KEGG ID: R00432 click to see details on this item	6.2.1.4Name: succinate---CoA ligase (GDP-forming) Other names: succinyl-CoA synthetase (GDP-forming), succinyl coenzyme A synthetase (guanosine diphosphate-forming), succinate thiokinase, succinic thiokinase, succinyl coenzyme A synthetase, succinate-phosphorylating enzyme, P-enzyme, SCS, G-STK, succinyl coenzyme A synthetase (GDP-forming), succinyl CoA synthetase, succinyl coenzyme A synthetase click to see details on this item	[m] : gtpName: GTP Formula: C10H12N5O14P3 Charge: -4 click to see details on this item + succName: Succinate Formula: C4H4O4 Charge: -2 click to see details on this item + coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item		gdpName: GDP Formula: C10H12N5O11P2 Charge: -3 click to see details on this item + piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item + succoaName: Succinyl-CoA Formula: C25H35N7O19P3S Charge: -5 click to see details on this item	(sucl-1 | sucl-2) & sucg-1	TCA cycle
RM00405Name: Succinate:CoA ligase (ADP-forming) Type: Regular Location: Mitochondria KEGG ID: R00405 click to see details on this item	6.2.1.5Name: succinate---CoA ligase (ADP-forming) Other names: succinyl-CoA synthetase (ADP-forming), succinic thiokinase, succinate thiokinase, succinyl-CoA synthetase, succinyl coenzyme A synthetase (adenosine diphosphate-forming), succinyl coenzyme A synthetase, A-STK (adenin nucleotide-linked succinate thiokinase), STK, A-SCS click to see details on this item	[m] : atpName: ATP Formula: C10H12N5O13P3 Charge: -4 click to see details on this item + succName: Succinate Formula: C4H4O4 Charge: -2 click to see details on this item + coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item		adpName: ADP Formula: C10H12N5O10P2 Charge: -3 click to see details on this item + piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item + succoaName: Succinyl-CoA Formula: C25H35N7O19P3S Charge: -5 click to see details on this item	(sucl-1 | sucl-2) & suca-1	TCA cycle
RM01082Name: (S)-malate hydro-lyase (fumarate-forming) Type: Regular Location: Mitochondria KEGG ID: R01082 click to see details on this item	4.2.1.2Name: fumarate hydratase Other names: fumarase, L-malate hydro-lyase, (S)-malate hydro-lyase click to see details on this item	[m] : mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item		fumName: Fumarate Formula: C4H2O4 Charge: -2 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item	fum-1	TCA cycle
RM00342Name: (S)-malate:NAD+ oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R00342 click to see details on this item	1.1.1.37Name: malate dehydrogenase Other names: malic dehydrogenase, L-malate dehydrogenase, NAD-L-malate dehydrogenase, malic acid dehydrogenase, NAD-dependent malic dehydrogenase, NAD-malate dehydrogenase, NAD-malic dehydrogenase, malate (NAD) dehydrogenase, NAD-dependent malate dehydrogenase, NAD-specific malate dehydrogenase, NAD-linked malate dehydrogenase, MDH, L-malate-NAD+ oxidoreductase click to see details on this item	[m] : mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item		oaaName: Oxaloacetate Formula: C4H2O5 Charge: -2 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	mdh-1 | mdh-2	TCA cycle
RMC0183Name: fumarate reductase Type: Regular Location: Mitochondria KEGG ID: R02164 click to see details on this item	1.3.5.4Name: fumarate reductase (quinol) Other names: FRD, menaquinol-fumarate oxidoreductase, succinate dehydrogenase (menaquinone), succinate:menaquinone oxidoreductase, fumarate reductase (menaquinone), complex II (ambiguous) click to see details on this item	[m] : rq9h2Name: Rhodoquinonol-9 Formula: C53H83NO3 Charge: 0 click to see details on this item + fumName: Fumarate Formula: C4H2O4 Charge: -2 click to see details on this item		rq9Name: Rhodoquinone-9 Formula: C53H81NO3 Charge: 0 click to see details on this item + succName: Succinate Formula: C4H4O4 Charge: -2 click to see details on this item	F48E8.3	TCA cycle
RC00342Name: (S)-malate:NAD+ oxidoreductase Type: Regular Location: Cytosol KEGG ID: R00342 click to see details on this item	1.1.1.37Name: malate dehydrogenase Other names: malic dehydrogenase, L-malate dehydrogenase, NAD-L-malate dehydrogenase, malic acid dehydrogenase, NAD-dependent malic dehydrogenase, NAD-malate dehydrogenase, NAD-malic dehydrogenase, malate (NAD) dehydrogenase, NAD-dependent malate dehydrogenase, NAD-specific malate dehydrogenase, NAD-linked malate dehydrogenase, MDH, L-malate-NAD+ oxidoreductase click to see details on this item	[c] : mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item		oaaName: Oxaloacetate Formula: C4H2O5 Charge: -2 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	mdh-1	TCA cycle
RC01082Name: (S)-malate hydro-lyase (fumarate-forming) (cytosolic) Type: Regular Location: Cytosol KEGG ID: R01082 click to see details on this item	4.2.1.2Name: fumarate hydratase Other names: fumarase, L-malate hydro-lyase, (S)-malate hydro-lyase click to see details on this item	[c] : mal-LName: L-Malate Formula: C4H4O5 Charge: -2 click to see details on this item		fumName: Fumarate Formula: C4H2O4 Charge: -2 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item	fum-1	TCA cycle

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