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  • ? : A single character. E.g., trehalose?phosphatase covers both trehalose phosphatase and trehalose-phosphatase, of which, only the latter fits the nomenclature used in this database.
  • * : Any number of characters. E.g.,tre-* brings all genes from trehalase family; coenzyme*A covers coenzyme A, coenzyme-A, and coenzymeA.
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PEAPathway Enrichment Analysis
WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal
Metabolite Overview
Abbreviation ..................................................... : icit
Name ..................................................... : Isocitrate, etc.Isocitric acid, 1-Hydroxytricarballylic acid, 1-Hydroxypropane-1,2,3-tricarboxylic acid
Model ID ..................................................... : C00311
KEGG ID (?) Compounds in KEGG database that match this compound. ..................................................... : C00311
Formula ..................................................... : C6H5O7
Charge ..................................................... : -3
Localization ..................................................... : Mitochondria, Cytosol, Extracellular
BiGG matches (?) Compounds in BiGG database that match this compound. ..................................................... : icit
Other associations ..................................................... : See reaction table below (9 reactions in total)

In WormPaths (?) Pathway maps where this metabolite is represented are listed here.

Letters after map name indicate the compartments the metabolite is placed in the map:

(c) Cytosol
(m) Mitochondria
(e) Extracellular space ..................................................... 		: Glyoxylate and dicarboxylate metabolism (m), TCA cycle (c,m)
Comments
ERROR
Reactions
ID Enzyme Reactants Products Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses. 		Pathway
RCC0001Name: citrate hydro-lyase (cis-aconitate-forming)
Type: Regular
Location: Cytosol
KEGG ID: R01325;R01900

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4.2.1.3Name: aconitate hydratase
Other names: cis-aconitase, aconitase, AcnB, 2-methylaconitate hydratase, citrate(isocitrate) hydro-lyase

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[c] : citName: Citrate
Formula: C6H5O7
Charge: -3




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icitName: Isocitrate
Formula: C6H5O7
Charge: -3




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aco-1
TCA cycle
RMC0001Name: isocitrate hydro-lyase (cis-aconitate-forming)
Type: Regular
Location: Mitochondria
KEGG ID: R01325;R01900

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4.2.1.3Name: aconitate hydratase
Other names: cis-aconitase, aconitase, AcnB, 2-methylaconitate hydratase, citrate(isocitrate) hydro-lyase

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[m] : citName: Citrate
Formula: C6H5O7
Charge: -3




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icitName: Isocitrate
Formula: C6H5O7
Charge: -3




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aco-2
TCA cycle
RC00267Name: Isocitrate:NADP+ oxidoreductase
Type: Regular
Location: Cytosol
KEGG ID: R00267

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1.1.1.42Name: isocitrate dehydrogenase (NADP+)
Other names: oxalosuccinate decarboxylase, oxalsuccinic decarboxylase, isocitrate (NADP) dehydrogenase, isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase, NADP-specific isocitrate dehydrogenase, NADP-linked isocitrate dehydrogenase, NADP-dependent isocitrate dehydrogenase, NADP isocitric dehydrogenase, isocitrate dehydrogenase (NADP-dependent), NADP-dependent isocitric dehydrogenase, triphosphopyridine nucleotide-linked isocitrate dehydrogenase-oxalosuccinate carboxylase, NADP+-linked isocitrate dehydrogenase, IDH (ambiguous), dual-cofactor-specific isocitrate dehydrogenase, NADP+-ICDH, NADP+-IDH, IDP, IDP1, IDP2, IDP3

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[c] : icitName: Isocitrate
Formula: C6H5O7
Charge: -3




click to see details on this item + nadpName: Nicotinamide adenine dinucleotide phosphate
Formula: C21H25N7O17P3
Charge: -3




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akgName: 2-Oxoglutarate
Formula: C5H4O5
Charge: -2




click to see details on this item + co2Name: CO2
Formula: CO2
Charge: 0




click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced
Formula: C21H26N7O17P3
Charge: -4




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idh-1
TCA cycle
RM00267Name: Isocitrate:NADP+ oxidoreductase
Type: Regular
Location: Mitochondria
KEGG ID: R00267

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1.1.1.42Name: isocitrate dehydrogenase (NADP+)
Other names: oxalosuccinate decarboxylase, oxalsuccinic decarboxylase, isocitrate (NADP) dehydrogenase, isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase, NADP-specific isocitrate dehydrogenase, NADP-linked isocitrate dehydrogenase, NADP-dependent isocitrate dehydrogenase, NADP isocitric dehydrogenase, isocitrate dehydrogenase (NADP-dependent), NADP-dependent isocitric dehydrogenase, triphosphopyridine nucleotide-linked isocitrate dehydrogenase-oxalosuccinate carboxylase, NADP+-linked isocitrate dehydrogenase, IDH (ambiguous), dual-cofactor-specific isocitrate dehydrogenase, NADP+-ICDH, NADP+-IDH, IDP, IDP1, IDP2, IDP3

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[m] : icitName: Isocitrate
Formula: C6H5O7
Charge: -3




click to see details on this item + nadpName: Nicotinamide adenine dinucleotide phosphate
Formula: C21H25N7O17P3
Charge: -3




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akgName: 2-Oxoglutarate
Formula: C5H4O5
Charge: -2




click to see details on this item + co2Name: CO2
Formula: CO2
Charge: 0




click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced
Formula: C21H26N7O17P3
Charge: -4




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idh-1 | idh-2
TCA cycle
RM00709Name: Isocitrate:NAD+ oxidoreductase (decarboxylating)
Type: Regular
Location: Mitochondria
KEGG ID: R00709

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1.1.1.41Name: isocitrate dehydrogenase (NAD+)
Other names: isocitric dehydrogenase, beta-ketoglutaric-isocitric carboxylase, isocitric acid dehydrogenase, NAD dependent isocitrate dehydrogenase, NAD isocitrate dehydrogenase, NAD-linked isocitrate dehydrogenase, NAD-specific isocitrate dehydrogenase, NAD isocitric dehydrogenase, isocitrate dehydrogenase (NAD), IDH (ambiguous), nicotinamide adenine dinucleotide isocitrate dehydrogenase

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[m] : icitName: Isocitrate
Formula: C6H5O7
Charge: -3




click to see details on this item + nadName: Nicotinamide adenine dinucleotide
Formula: C21H26N7O14P2
Charge: -1




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akgName: 2-Oxoglutarate
Formula: C5H4O5
Charge: -2




click to see details on this item + co2Name: CO2
Formula: CO2
Charge: 0




click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced
Formula: C21H27N7O14P2
Charge: -2




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idha-1 & idhb-1 & (idhg-1 | idhg-2)
TCA cycle
RM00479Name: isocitrate lyase
Type: Regular
Location: Mitochondria
KEGG ID: R00479

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4.1.3.1Name: isocitrate lyase
Other names: isocitrase, isocitritase, isocitratase, threo-Ds-isocitrate glyoxylate-lyase, isocitrate glyoxylate-lyase

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[m] : icitName: Isocitrate
Formula: C6H5O7
Charge: -3




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glxName: Glyoxylate
Formula: C2H1O3
Charge: -1




click to see details on this item + succName: Succinate
Formula: C4H4O4
Charge: -2




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icl-1
Glyoxylate and dicarboxylate metabolism
TCE5329Name: Isocitrate transport
Type: Transport
Location: Cytosol, Extracellular
KEGG ID: NA

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Not applicable
icitName: Isocitrate
Formula: C6H5O7
Charge: -3




click to see details on this item[e]
icitName: Isocitrate
Formula: C6H5O7
Charge: -3




click to see details on this item[c]
Not determined
Transport
TCM1047Name: Isocitrate and Citrate transport
Type: Transport
Location: Mitochondria, Cytosol
KEGG ID: NA

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Not applicable
citName: Citrate
Formula: C6H5O7
Charge: -3




click to see details on this item[c] + icitName: Isocitrate
Formula: C6H5O7
Charge: -3




click to see details on this item[m]
citName: Citrate
Formula: C6H5O7
Charge: -3




click to see details on this item[m] + icitName: Isocitrate
Formula: C6H5O7
Charge: -3




click to see details on this item[c]
Not determined
Transport
EX00311Name: Isocitrate exchange
Type: Exchange
Location: Extracellular
KEGG ID: NA

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Not applicable
icitName: Isocitrate
Formula: C6H5O7
Charge: -3




click to see details on this item[e]
Not applicable
Exchange with the environment
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