Network Biomass WormPaths

PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal

Metabolite Overview

Abbreviation .....................................................	:	dc2coa
Name .....................................................	:	trans-Dec-2-enoyl-CoA, etc.(2E)-Decenoyl-CoA
Model ID .....................................................	:	C05275
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C05275
Formula .....................................................	:	C31H48N7O17P3S
Charge .....................................................	:	-4
Localization .....................................................	:	Mitochondria, Cytosol
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	dc2coa
Other associations .....................................................	:	See reaction table below.
In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Mitochondrial fatty acid degradation (m), Peroxisomal fatty acid degradation (c)

iCEL1314

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RM04744Name: (S)-Hydroxydecanoyl-CoA hydro-lyase Type: Regular Location: Mitochondria KEGG ID: R04744 click to see details on this item	4.2.1.17Name: enoyl-CoA hydratase Other names: enoyl hydrase, unsaturated acyl-CoA hydratase, beta-hydroxyacyl-CoA dehydrase, beta-hydroxyacid dehydrase, hydratase, enoyl coenzyme A, acyl coenzyme A hydrase, crotonase, crotonyl hydrase, 2-octenoyl coenzyme A hydrase, enoyl coenzyme A hydratase, 2-enoyl-CoA hydratase, short-chain enoyl-CoA hydratase, ECH, trans-2-enoyl-CoA hydratase, enoyl coenzyme A hydrase (D), enoyl coenzyme A hydrase (L), short chain enoyl coenzyme A hydratase, D-3-hydroxyacyl-CoA dehydratase, enol-CoA hydratase click to see details on this item	[m] : 3hdcoaName: (S)-3-Hydroxydecanoyl-CoA Formula: C31H50N7O18P3S Charge: -4 click to see details on this item		dc2coaName: trans-Dec-2-enoyl-CoA Formula: C31H48N7O17P3S Charge: -4 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item	(ech-6 | ech-7) | (ech-1.2 | ech-1.1) | ech-3	Mitochondrial fatty acid degradation
RM04753Name: trans-Dec-2-enoyl-CoA reductase Type: Regular Location: Mitochondria KEGG ID: R04753 click to see details on this item	1.3.1.38Name: trans-2-enoyl-CoA reductase (NADPH) Other names: NADPH-dependent trans-2-enoyl-CoA reductase, reductase, trans-enoyl coenzyme A, trans-2-enoyl-CoA reductase (NADPH2) click to see details on this item	[m] : dc2coaName: trans-Dec-2-enoyl-CoA Formula: C31H48N7O17P3S Charge: -4 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + nadphName: Nicotinamide adenine dinucleotide phosphate - reduced Formula: C21H26N7O17P3 Charge: -4 click to see details on this item		dcacoaName: Decanoyl-CoA (n-C10:0CoA) Formula: C31H50N7O17P3S Charge: -4 click to see details on this item + nadpName: Nicotinamide adenine dinucleotide phosphate Formula: C21H25N7O17P3 Charge: -3 click to see details on this item	mecr-1 | Y48A6B.9	Mitochondrial fatty acid degradation
RM04754Name: Decanoyl-CoA:(acceptor) 2,3-oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R04754 click to see details on this item	1.3.8.7Name: medium-chain acyl-CoA dehydrogenase Other names: fatty acyl coenzyme A dehydrogenase (ambiguous), acyl coenzyme A dehydrogenase (ambiguous), acyl dehydrogenase (ambiguous), fatty-acyl-CoA dehydrogenase (ambiguous), acyl CoA dehydrogenase (ambiguous), general acyl CoA dehydrogenase (ambiguous), medium-chain acyl-coenzyme A dehydrogenase, acyl-CoA:(acceptor) 2,3-oxidoreductase (ambiguous), ACADM (gene name). click to see details on this item	[m] : dcacoaName: Decanoyl-CoA (n-C10:0CoA) Formula: C31H50N7O17P3S Charge: -4 click to see details on this item + etfoxName: Electron transfer flavoprotein oxidized Formula: R Charge: 0 click to see details on this item		dc2coaName: trans-Dec-2-enoyl-CoA Formula: C31H48N7O17P3S Charge: -4 click to see details on this item + etfrdName: Electron transfer flavoprotein reduced Formula: RH2 Charge: 0 click to see details on this item	(acdh-7 | acdh-8 | acdh-10)	Mitochondrial fatty acid degradation
RCC0168Name: Decanoyl-CoA oxidase Type: Regular Location: Cytosol KEGG ID: R00388 click to see details on this item	1.3.3.6Name: acyl-CoA oxidase Other names: fatty acyl-CoA oxidase, acyl coenzyme A oxidase, fatty acyl-coenzyme A oxidase click to see details on this item	[c] : o2Name: O2 Formula: O2 Charge: 0 click to see details on this item + dcacoaName: Decanoyl-CoA (n-C10:0CoA) Formula: C31H50N7O17P3S Charge: -4 click to see details on this item		h2o2Name: Hydrogen peroxide Formula: H2O2 Charge: 0 click to see details on this item + dc2coaName: trans-Dec-2-enoyl-CoA Formula: C31H48N7O17P3S Charge: -4 click to see details on this item	acox-1.5 | acox-1.1 | acox-1.2 | acox-1.3 | acox-1.4 | acox-3 | acox-1.6	Peroxisomal fatty acid degradation
RCC0086Name: peroxisomal multifunctional enzyme type 2 (acting on dc2coa) Type: Regular Location: Cytosol KEGG ID: R04743;R04744 click to see details on this item	4.2.1.17Name: enoyl-CoA hydratase Other names: enoyl hydrase, unsaturated acyl-CoA hydratase, beta-hydroxyacyl-CoA dehydrase, beta-hydroxyacid dehydrase, hydratase, enoyl coenzyme A, acyl coenzyme A hydrase, crotonase, crotonyl hydrase, 2-octenoyl coenzyme A hydrase, enoyl coenzyme A hydratase, 2-enoyl-CoA hydratase, short-chain enoyl-CoA hydratase, ECH, trans-2-enoyl-CoA hydratase, enoyl coenzyme A hydrase (D), enoyl coenzyme A hydrase (L), short chain enoyl coenzyme A hydratase, D-3-hydroxyacyl-CoA dehydratase, enol-CoA hydratase click to see details on this item 1.1.1.211Name: long-chain-3-hydroxyacyl-CoA dehydrogenase Other names: beta-hydroxyacyl-CoA dehydrogenase, long-chain 3-hydroxyacyl coenzyme A dehydrogenase, 3-hydroxyacyl-CoA dehydrogenase, LCHAD click to see details on this item 1.1.1.35Name: 3-hydroxyacyl-CoA dehydrogenase Other names: beta-hydroxyacyl dehydrogenase, beta-keto-reductase, 3-keto reductase, 3-hydroxyacyl coenzyme A dehydrogenase, beta-hydroxyacyl-coenzyme A synthetase, beta-hydroxyacylcoenzyme A dehydrogenase, beta-hydroxybutyrylcoenzyme A dehydrogenase, 3-hydroxyacetyl-coenzyme A dehydrogenase, L-3-hydroxyacyl coenzyme A dehydrogenase, L-3-hydroxyacyl CoA dehydrogenase, beta-hydroxyacyl CoA dehydrogenase, 3beta-hydroxyacyl coenzyme A dehydrogenase, 3-hydroxybutyryl-CoA dehydrogenase, beta-ketoacyl-CoA reductase, beta-hydroxy acid dehydrogenase, 3-L-hydroxyacyl-CoA dehydrogenase, 3-hydroxyisobutyryl-CoA dehydrogenase, 1-specific DPN-linked beta-hydroxybutyric dehydrogenase click to see details on this item	[c] : dc2coaName: trans-Dec-2-enoyl-CoA Formula: C31H48N7O17P3S Charge: -4 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item		3odcoaName: 3-Oxodecanoyl-CoA Formula: C31H48N7O18P3S Charge: -4 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item	dhs-28 | maoc-1	Peroxisomal fatty acid degradation

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