Network Biomass WormPaths

PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal

Metabolite Overview

Abbreviation .....................................................	:	h2s
Name .....................................................	:	Hydrogen sulfide, etc.Hydrogen-sulfide, H2S, Sulfide
Model ID .....................................................	:	C00283
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C00283
Formula .....................................................	:	H2S
Charge .....................................................	:	0
Localization .....................................................	:	Mitochondria, Cytosol
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	h2s
Other associations .....................................................	:	See reaction table below (6 reactions in total)
In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Cysteine metabolism (c), Sulfur metabolism (c,m)

iCEL1314

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RM03524Name: L-cysteine hydrogen-sulfide-lyase (adding HCN) Type: Regular Location: Mitochondria KEGG ID: R03524 click to see details on this item	4.4.1.9Name: L-3-cyanoalanine synthase Other names: beta-cyanoalanine synthase, beta-cyanoalanine synthetase, beta-cyano-L-alanine synthase, L-cysteine hydrogen-sulfide-lyase (adding HCN) click to see details on this item	[m] : cys-LName: L-Cysteine Formula: C3H7NO2S Charge: 0 click to see details on this item + cyanName: Hydrogen cyanide Formula: CHN Charge: 0 click to see details on this item		h2sName: Hydrogen sulfide Formula: H2S Charge: 0 click to see details on this item + cyanalaName: Beta cyanoalanine Formula: C4H5N2O2 Charge: -1 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	cysl-2	Sulfur metabolism
RC00782Name: L-Cysteine hydrogen-sulfide-lyase (deaminating, pyruvate-forming) Type: Regular Location: Cytosol KEGG ID: R00782 click to see details on this item	4.4.1.1Name: cystathionine gamma-lyase Other names: homoserine deaminase, homoserine dehydratase, cystine desulfhydrase, cysteine desulfhydrase, gamma-cystathionase, cystathionase, homoserine deaminase-cystathionase, gamma-CTL, cystalysin, cysteine lyase, L-cystathionine cysteine-lyase (deaminating) click to see details on this item	[c] : cys-LName: L-Cysteine Formula: C3H7NO2S Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		h2sName: Hydrogen sulfide Formula: H2S Charge: 0 click to see details on this item + nh4Name: Ammonium Formula: H4N Charge: 1 click to see details on this item + pyrName: Pyruvate Formula: C3H3O3 Charge: -1 click to see details on this item	cbl-1 | cth-1 | cth-2	Cysteine metabolism
RC00897Name: O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase Type: Regular Location: Cytosol KEGG ID: R00897 click to see details on this item	2.5.1.47Name: cysteine synthase Other names: O-acetyl-L-serine sulfhydrylase, O-acetyl-L-serine sulfohydrolase, O-acetylserine (thiol)-lyase, O-acetylserine (thiol)-lyase A, O-acetylserine sulfhydrylase, O3-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide), acetylserine sulfhydrylase, cysteine synthetase, S-sulfocysteine synthase, 3-O-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase, O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase click to see details on this item	[c] : acserName: O-Acetyl-L-serine Formula: C5H9NO4 Charge: 0 click to see details on this item + h2sName: Hydrogen sulfide Formula: H2S Charge: 0 click to see details on this item		acName: Acetate Formula: C2H3O2 Charge: -1 click to see details on this item + cys-LName: L-Cysteine Formula: C3H7NO2S Charge: 0 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	F01D4.8 | F13B12.4 | F59A7.7 | T25D3.3 | cysl-1 | cysl-2 | cysl-3 | cysl-4	Cysteine metabolism
RMC0077Name: Sulfide:quinone oxidoreductase Type: Regular Location: Mitochondria KEGG ID: NA click to see details on this item	1.8.5.-Name: sulfide:quinone oxidoreductase click to see details on this item	[m] : h2sName: Hydrogen sulfide Formula: H2S Charge: 0 click to see details on this item + qName: Ubiquinone Formula: C14H18O4 Charge: 0 click to see details on this item		sName: Sulfur Formula: S Charge: 0 click to see details on this item + qh2Name: Ubiquinol Formula: C14H20O4 Charge: 0 click to see details on this item	sqrd-1	Sulfur metabolism
RM01875Name: Thiosulfate:thiol sulfurtransferase Type: Regular Location: Mitochondria KEGG ID: R01875 click to see details on this item	2.8.1.3Name: thiosulfate---thiol sulfurtransferase Other names: glutathione-dependent thiosulfate reductase, sulfane reductase, sulfane sulfurtransferase click to see details on this item	[m] : so3Name: Sulfite Formula: O3S Charge: -2 click to see details on this item + h2sName: Hydrogen sulfide Formula: H2S Charge: 0 click to see details on this item + gthoxName: Oxidized glutathione Formula: C20H30N6O12S2 Charge: -2 click to see details on this item		tsulName: Thiosulfate Formula: O3S2 Charge: -2 click to see details on this item + (2) gthrdName: Reduced glutathione Formula: C10H16N3O6S Charge: -1 click to see details on this item	Unknown	Sulfur metabolism
TCM5008Name: sulfide transport to and from mitochondrion Type: Transport Location: Mitochondria, Cytosol KEGG ID: NA click to see details on this item	Not applicable	h2sName: Hydrogen sulfide Formula: H2S Charge: 0 click to see details on this item[m]		h2sName: Hydrogen sulfide Formula: H2S Charge: 0 click to see details on this item[c]	Not determined	Transport

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