WormFlux: mechanistic analysis of C. elegans metabolism

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Use wild characters " ? " and " * " for efficient search:

? : A single character. E.g., trehalose?phosphatase covers both trehalose phosphatase and trehalose-phosphatase, of which, only the latter fits the nomenclature used in this database.
* : Any number of characters. E.g.,tre-* brings all genes from trehalase family; coenzyme*A covers coenzyme A, coenzyme-A, and coenzymeA.

Network Biomass WormPaths

PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal

Enzyme Overview

Enzyme (?) Identification in Enzyme Commission (EC) numbering system. .....................................................	:	3.1.1.4
Name .....................................................	:	Phospholipase A2, etc.Lecithinase A, Phosphatidase, Phosphatidolipase, Phospholipase A
KO (?) The KEGG orthology group (KO) that is associated with this enzyme. .....................................................	:	K16343PLA2G6 IPLA2; calcium-independent phospholipase A2 [EC:3.1.1.4], K16815PNPLA8; calcium-independent phospholipase A2-gamma, K01047PLA2G SPLA2; secretory phospholipase A2 [EC:3.1.1.4], K13619DDHD1; phospholipase DDHD1 [EC:3.1.1.-]
Genes .....................................................	:	C07E3.9, Y69A2AL.2, ipla-1, ipla-2, ipla-3, ipla-4, ipla-5, ipla-6, ipla-7
Localization .....................................................	:	Cytosol
Other associations .....................................................	:	See reaction table below (8 reactions in total)

External links

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RC07379Name: Plasmenylethanolamine 2-acylhydrolase Type: Regular Location: Cytosol KEGG ID: R07379 click to see details on this item	3.1.1.4Name: phospholipase A2 Other names: lecithinase A, phosphatidase, phosphatidolipase, phospholipase A click to see details on this item	[c] : alkenac2gpeName: 1-alkenyl 2-acylglycerol 3-phosphoethanolamine plasmalogen Formula: C6H12NO7PRRC2H2 Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		alken2gpeName: 1-Alkenylglycerophosphoethanolamine Formula: C5H13NO6PRC2H2 Charge: 0 click to see details on this item + Rtotal6Name: R total 6 Formula: CO2R Charge: -1 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	ipla-1 \| ipla-2 \| ipla-3 \| ipla-4 \| ipla-5 \| ipla-6 \| ipla-7 \| C07E3.9 \| Y69A2AL.2	Ether lipid metabolism
RC07387Name: Plasmanylcholine 2-acylhydrolase Type: Regular Location: Cytosol KEGG ID: R07387 click to see details on this item	3.1.1.4Name: phospholipase A2 Other names: lecithinase A, phosphatidase, phosphatidolipase, phospholipase A click to see details on this item	[c] : akac2gcholName: 1-alkyl 2-acylglycerol 3-phosphocholine Formula: C9H18NO7PRRC2H4 Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		ak2lgcholName: 1-Alkyl-2-lyso-sn-glycero-3-phosphocholine Formula: C8H19NO6PRC2H4 Charge: 0 click to see details on this item + Rtotal6Name: R total 6 Formula: CO2R Charge: -1 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	ipla-1 \| ipla-2 \| ipla-3 \| ipla-4 \| ipla-5 \| ipla-6 \| ipla-7 \| C07E3.9 \| Y69A2AL.2	Ether lipid metabolism
RC01315Name: Phosphatidylcholine 2-acylhydrolase Type: Regular Location: Cytosol KEGG ID: R01315 click to see details on this item	3.1.1.4Name: phospholipase A2 Other names: lecithinase A, phosphatidase, phosphatidolipase, phospholipase A click to see details on this item	[c] : h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + pcholName: Phosphatidylcholine Formula: C8H18NO4PFULLRCO2FULLR2CO2 Charge: 0 click to see details on this item		Rtotal2Name: R total 2 position Formula: CO2FULLR2 Charge: -1 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item + lpcholName: Lysophosphatidylcholine Formula: C8H19NO5PFULLRCO2 Charge: 0 click to see details on this item	ipla-1 \| ipla-2 \| ipla-3 \| ipla-4 \| ipla-5 \| ipla-6 \| ipla-7 \| C07E3.9 \| Y69A2AL.2	Glycerophospholipid metabolism
RC02053Name: Phosphatidylethanolamine 2-acylhydrolase Type: Regular Location: Cytosol KEGG ID: R02053 click to see details on this item	3.1.1.4Name: phospholipase A2 Other names: lecithinase A, phosphatidase, phosphatidolipase, phospholipase A click to see details on this item	[c] : peName: Phosphatidylethanolamine Formula: C5H12NO4PFULLRCO2FULLR2CO2 Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		Rtotal2Name: R total 2 position Formula: CO2FULLR2 Charge: -1 click to see details on this item + acg3peName: 1-Acyl-sn-glycero-3-phosphoethanolamine;2-Acyl-sn-glycero-3-phosphoethanolamine Formula: C6H13NO7PR Charge: 0 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	ipla-1 \| ipla-2 \| ipla-3 \| ipla-4 \| ipla-5 \| ipla-6 \| ipla-7 \| C07E3.9 \| Y69A2AL.2	Glycerophospholipid metabolism
DGR0019Name: Bacterial phosphatidylethanolamine degradation Type: Degradation Location: Cytosol KEGG ID: R02053 click to see details on this item	3.1.1.4Name: phospholipase A2 Other names: lecithinase A, phosphatidase, phosphatidolipase, phospholipase A click to see details on this item	[c] : pe_BACName: Phosphatidylethanolamine (bacteria) Formula: C7H12NO8PR2 Charge: 0 click to see details on this item + (2) h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		g3peName: sn-Glycero-3-phosphoethanolamine Formula: C5H14NO6P Charge: 0 click to see details on this item + (2) Rtotal_BACName: R total from bacterial diet Formula: RCO2 Charge: -1 click to see details on this item + (2) hName: H+ Formula: H Charge: 1 click to see details on this item	ipla-1 \| ipla-2 \| ipla-3 \| ipla-4 \| ipla-5 \| ipla-6 \| ipla-7 \| C07E3.9 \| Y69A2AL.2	Bacterial digestion
DGR0021Name: Bacterial phosphatidylglycerol degradation Type: Degradation Location: Cytosol KEGG ID: NA click to see details on this item	3.1.1.4Name: phospholipase A2 Other names: lecithinase A, phosphatidase, phosphatidolipase, phospholipase A click to see details on this item	[c] : pg_BACName: Phosphatidylglycerol (bacteria) Formula: C8H12O10PR2 Charge: -1 click to see details on this item + (3) h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		glyc3pName: Glycerol 3-phosphate Formula: C3H7O6P Charge: -2 click to see details on this item + glycName: Glycerol Formula: C3H8O3 Charge: 0 click to see details on this item + (2) Rtotal_BACName: R total from bacterial diet Formula: RCO2 Charge: -1 click to see details on this item + (3) hName: H+ Formula: H Charge: 1 click to see details on this item	ipla-1 \| ipla-2 \| ipla-3 \| ipla-4 \| ipla-5 \| ipla-6 \| ipla-7 \| C07E3.9 \| Y69A2AL.2	Bacterial digestion
DGR0024Name: Bacterial phosphatidate degradation Type: Degradation Location: Cytosol KEGG ID: NA click to see details on this item	3.1.1.4Name: phospholipase A2 Other names: lecithinase A, phosphatidase, phosphatidolipase, phospholipase A click to see details on this item	[c] : pa_BACName: Phosphatidate (bacteria) Formula: C5H5O8PR2 Charge: -2 click to see details on this item + (3) h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		glycName: Glycerol Formula: C3H8O3 Charge: 0 click to see details on this item + (2) Rtotal_BACName: R total from bacterial diet Formula: RCO2 Charge: -1 click to see details on this item + (2) hName: H+ Formula: H Charge: 1 click to see details on this item + piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item	ipla-1 \| ipla-2 \| ipla-3 \| ipla-4 \| ipla-5 \| ipla-6 \| ipla-7 \| C07E3.9 \| Y69A2AL.2	Bacterial digestion
DGR0026Name: Bacterial phosphatidylserine degradation Type: Degradation Location: Cytosol KEGG ID: NA click to see details on this item	3.1.1.4Name: phospholipase A2 Other names: lecithinase A, phosphatidase, phosphatidolipase, phospholipase A click to see details on this item	[c] : ps_BACName: Phosphatidylserine (bacteria) Formula: C8H11NO10PR2 Charge: -1 click to see details on this item + (3) h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		pser-LName: O-Phospho-L-serine Formula: C3H6NO6P Charge: -2 click to see details on this item + glycName: Glycerol Formula: C3H8O3 Charge: 0 click to see details on this item + (2) Rtotal_BACName: R total from bacterial diet Formula: RCO2 Charge: -1 click to see details on this item + (3) hName: H+ Formula: H Charge: 1 click to see details on this item	ipla-1 \| ipla-2 \| ipla-3 \| ipla-4 \| ipla-5 \| ipla-6 \| ipla-7 \| C07E3.9 \| Y69A2AL.2	Bacterial digestion

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