WormFlux: mechanistic analysis of C. elegans metabolism

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(?) Enter a search word or phrase (left box), optionally select an appropriate field (middle), and hit the search button or press enter. This search engine is NOT case sensitive.

Use wild characters " ? " and " * " for efficient search:

? : A single character. E.g., trehalose?phosphatase covers both trehalose phosphatase and trehalose-phosphatase, of which, only the latter fits the nomenclature used in this database.
* : Any number of characters. E.g.,tre-* brings all genes from trehalase family; coenzyme*A covers coenzyme A, coenzyme-A, and coenzymeA.

Network Biomass WormPaths

PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal

Enzyme Overview

Enzyme (?) Identification in Enzyme Commission (EC) numbering system. .....................................................	:	2.3.1.9
Name .....................................................	:	Acetyl-CoA C-acetyltransferase, etc.Acetoacetyl-CoA thiolase, Beta-acetoacetyl coenzyme A thiolase, 2-methylacetoacetyl-CoA thiolase [misleading], 3-oxothiolase, Acetyl coenzyme A thiolase, Acetyl-CoA acetyltransferase, Acetyl-CoA:N-acetyltransferase, Thiolase II
KO (?) The KEGG orthology group (KO) that is associated with this enzyme. .....................................................	:	K00626E2.3.1.9 atoB; acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
Genes .....................................................	:	T02G5.4, T02G5.7, kat-1
Localization .....................................................	:	Mitochondria, Cytosol
Other associations .....................................................	:	See reaction table below.

External links

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RM01177Name: butanoyl-CoA:acetyl-CoA C-butanoyltransferase Type: Regular Location: Mitochondria KEGG ID: R01177 click to see details on this item	2.3.1.16Name: acetyl-CoA C-acyltransferase Other names: beta-ketothiolase, 3-ketoacyl-CoA thiolase, KAT, beta-ketoacyl coenzyme A thiolase, beta-ketoacyl-CoA thiolase, beta-ketoadipyl coenzyme A thiolase, beta-ketoadipyl-CoA thiolase, 3-ketoacyl CoA thiolase, 3-ketoacyl coenzyme A thiolase, 3-ketoacyl thiolase, 3-ketothiolase, 3-oxoacyl-CoA thiolase, 3-oxoacyl-coenzyme A thiolase, 6-oxoacyl-CoA thiolase, acetoacetyl-CoA beta-ketothiolase, acetyl-CoA acyltransferase, ketoacyl-CoA acyltransferase, ketoacyl-coenzyme A thiolase, long-chain 3-oxoacyl-CoA thiolase, oxoacyl-coenzyme A thiolase, pro-3-ketoacyl-CoA thiolase, thiolase I, 2-methylacetoacetyl-CoA thiolase [misleading] click to see details on this item 2.3.1.9Name: acetyl-CoA C-acetyltransferase Other names: acetoacetyl-CoA thiolase, beta-acetoacetyl coenzyme A thiolase, 2-methylacetoacetyl-CoA thiolase [misleading], 3-oxothiolase, acetyl coenzyme A thiolase, acetyl-CoA acetyltransferase, acetyl-CoA:N-acetyltransferase, thiolase II click to see details on this item	[m] : 3ohcoaName: 3-Oxohexanoyl-CoA Formula: C27H40N7O18P3S Charge: -4 click to see details on this item + coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item		accoaName: Acetyl-CoA Formula: C23H34N7O17P3S Charge: -4 click to see details on this item + btcoaName: Butanoyl-CoA Formula: C25H38N7O17P3S Charge: -4 click to see details on this item	(B0303.3 \| acaa-2) \| (T02G5.7 \| kat-1)	Mitochondrial fatty acid degradation
RM00238Name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Type: Regular Location: Mitochondria KEGG ID: R00238 click to see details on this item	2.3.1.9Name: acetyl-CoA C-acetyltransferase Other names: acetoacetyl-CoA thiolase, beta-acetoacetyl coenzyme A thiolase, 2-methylacetoacetyl-CoA thiolase [misleading], 3-oxothiolase, acetyl coenzyme A thiolase, acetyl-CoA acetyltransferase, acetyl-CoA:N-acetyltransferase, thiolase II click to see details on this item	[m] : (2) accoaName: Acetyl-CoA Formula: C23H34N7O17P3S Charge: -4 click to see details on this item		coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + aacoaName: Acetoacetyl-CoA Formula: C25H36N7O18P3S Charge: -4 click to see details on this item	T02G5.7 \| kat-1	Ketone body metabolism
RC00238Name: Acetyl-CoA:acetyl-CoA C-acetyltransferase Type: Regular Location: Cytosol KEGG ID: R00238 click to see details on this item	2.3.1.9Name: acetyl-CoA C-acetyltransferase Other names: acetoacetyl-CoA thiolase, beta-acetoacetyl coenzyme A thiolase, 2-methylacetoacetyl-CoA thiolase [misleading], 3-oxothiolase, acetyl coenzyme A thiolase, acetyl-CoA acetyltransferase, acetyl-CoA:N-acetyltransferase, thiolase II click to see details on this item	[c] : (2) accoaName: Acetyl-CoA Formula: C23H34N7O17P3S Charge: -4 click to see details on this item		coaName: Coenzyme A Formula: C21H32N7O16P3S Charge: -4 click to see details on this item + aacoaName: Acetoacetyl-CoA Formula: C25H36N7O18P3S Charge: -4 click to see details on this item	T02G5.7	Fatty acid biosynthesis

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