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(?) Enter a search word or phrase (left box), optionally select an appropriate field (middle), and hit the search button or press enter. This search engine is NOT case sensitive.

Use wild characters " ? " and " * " for efficient search:
  • ? : A single character. E.g., trehalose?phosphatase covers both trehalose phosphatase and trehalose-phosphatase, of which, only the latter fits the nomenclature used in this database.
  • * : Any number of characters. E.g.,tre-* brings all genes from trehalase family; coenzyme*A covers coenzyme A, coenzyme-A, and coenzymeA.
Network Biomass WormPaths
PEAPathway Enrichment Analysis
WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal
Enzyme Overview
Enzyme (?) Identification in Enzyme Commission (EC) numbering system. ..................................................... : 1.5.1.15
Name ..................................................... : Methylenetetrahydrofolate dehydrogenase (NAD+), etc.Methylenetetrahydrofolate dehydrogenase (NAD+)
KO (?) The KEGG orthology group (KO) that is associated with this enzyme. ..................................................... : K13403MTHFD2; methylenetetrahydrofolate dehydrogenase(NAD+) / 510-methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.15 3.5.4.9]
Genes ..................................................... : dao-3
Localization ..................................................... : Cytosol
Other associations ..................................................... : See reaction table below.
Reactions
ID Enzyme Reactants Products Genes (?) Multiple genes are separated by OR (I) or AND (&).

I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme).
& indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme).

If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses. 		Pathway
RC01218Name: 5,10-methylenetetrahydrofolate:NAD+ oxidoreductase
Type: Regular
Location: Cytosol
KEGG ID: R01218

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1.5.1.15Name: methylenetetrahydrofolate dehydrogenase (NAD+)
Other names: methylenetetrahydrofolate dehydrogenase (NAD+)

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[c] : mlthfName: "5,10-Methylenetetrahydrofolate"
Formula: C20H21N7O6
Charge: -2




click to see details on this item + nadName: Nicotinamide adenine dinucleotide
Formula: C21H26N7O14P2
Charge: -1




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methfName: "5,10-Methenyltetrahydrofolate"
Formula: C20H20N7O6
Charge: -1




click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced
Formula: C21H27N7O14P2
Charge: -2




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dao-3
Folate cycle
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