Network Biomass WormPaths

PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal

Metabolite Overview

Abbreviation .....................................................	:	e4hglu
Name .....................................................	:	L-erythro-4-Hydroxyglutamate
Model ID .....................................................	:	C05947
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C05947
Formula .....................................................	:	C5H8NO5
Charge .....................................................	:	-1
Localization .....................................................	:	Mitochondria, Cytosol
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	e4hglu
Other associations .....................................................	:	See reaction table below.
In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Proline metabolism (c,m)

iCEL1314

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RM05051Name: L-erythro-4-Hydroxyglutamate:NAD+ oxidoreductase Type: Regular Location: Mitochondria KEGG ID: R05051 click to see details on this item	1.2.1.88Name: L-glutamate gamma-semialdehyde dehydrogenase Other names: 1-pyrroline-5-carboxylate dehydrogenase, Delta1-pyrroline-5-carboxylate dehydrogenase, 1-pyrroline dehydrogenase, pyrroline-5-carboxylate dehydrogenase, pyrroline-5-carboxylic acid dehydrogenase, L-pyrroline-5-carboxylate-NAD+ oxidoreductase, 1-pyrroline-5-carboxylate:NAD+ oxidoreductase, Delta1-pyrroline-5-carboxylic acid dehydrogenase click to see details on this item	[m] : 4hglusaName: L-4-Hydroxyglutamate semialdehyde Formula: C5H9NO4 Charge: 0 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item		e4hgluName: L-erythro-4-Hydroxyglutamate Formula: C5H8NO5 Charge: -1 click to see details on this item + (2) hName: H+ Formula: H Charge: 1 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item	alh-6	Proline metabolism
RM05052Name: L-erythro-4-hydroxyglutamate:2-oxoglutarate aminotransferase Type: Regular Location: Mitochondria KEGG ID: R05052 click to see details on this item	2.6.1.1Name: aspartate transaminase Other names: glutamic-oxaloacetic transaminase, glutamic-aspartic transaminase, transaminase A, AAT, AspT, 2-oxoglutarate-glutamate aminotransferase, aspartate alpha-ketoglutarate transaminase, aspartate aminotransferase, aspartate-2-oxoglutarate transaminase, aspartic acid aminotransferase, aspartic aminotransferase, aspartyl aminotransferase, AST, glutamate-oxalacetate aminotransferase, glutamate-oxalate transaminase, glutamic-aspartic aminotransferase, glutamic-oxalacetic transaminase, glutamic oxalic transaminase, GOT (enzyme) [ambiguous], L-aspartate transaminase, L-aspartate-alpha-ketoglutarate transaminase, L-aspartate-2-ketoglutarate aminotransferase, L-aspartate-2-oxoglutarate aminotransferase, L-aspartate-2-oxoglutarate-transaminase, L-aspartic aminotransferase, oxaloacetate-aspartate aminotransferase, oxaloacetate transferase, aspartate:2-oxoglutarate aminotransferase, glutamate oxaloacetate transaminase click to see details on this item	[m] : akgName: 2-Oxoglutarate Formula: C5H4O5 Charge: -2 click to see details on this item + e4hgluName: L-erythro-4-Hydroxyglutamate Formula: C5H8NO5 Charge: -1 click to see details on this item		4h2ogltName: 4-Hydroxy-2-oxoglutarate Formula: C5H4O6 Charge: -2 click to see details on this item + glu-LName: L-Glutamate Formula: C5H8NO4 Charge: -1 click to see details on this item	got-2.1 | got-2.2	Proline metabolism
RC05052Name: L-erythro-4-hydroxyglutamate:2-oxoglutarate aminotransferase Type: Regular Location: Cytosol KEGG ID: R05052 click to see details on this item	2.6.1.1Name: aspartate transaminase Other names: glutamic-oxaloacetic transaminase, glutamic-aspartic transaminase, transaminase A, AAT, AspT, 2-oxoglutarate-glutamate aminotransferase, aspartate alpha-ketoglutarate transaminase, aspartate aminotransferase, aspartate-2-oxoglutarate transaminase, aspartic acid aminotransferase, aspartic aminotransferase, aspartyl aminotransferase, AST, glutamate-oxalacetate aminotransferase, glutamate-oxalate transaminase, glutamic-aspartic aminotransferase, glutamic-oxalacetic transaminase, glutamic oxalic transaminase, GOT (enzyme) [ambiguous], L-aspartate transaminase, L-aspartate-alpha-ketoglutarate transaminase, L-aspartate-2-ketoglutarate aminotransferase, L-aspartate-2-oxoglutarate aminotransferase, L-aspartate-2-oxoglutarate-transaminase, L-aspartic aminotransferase, oxaloacetate-aspartate aminotransferase, oxaloacetate transferase, aspartate:2-oxoglutarate aminotransferase, glutamate oxaloacetate transaminase click to see details on this item	[c] : akgName: 2-Oxoglutarate Formula: C5H4O5 Charge: -2 click to see details on this item + e4hgluName: L-erythro-4-Hydroxyglutamate Formula: C5H8NO5 Charge: -1 click to see details on this item		4h2ogltName: 4-Hydroxy-2-oxoglutarate Formula: C5H4O6 Charge: -2 click to see details on this item + glu-LName: L-Glutamate Formula: C5H8NO4 Charge: -1 click to see details on this item	got-1.2	Proline metabolism
TCM1055Name: L-erythro-4-Hydroxyglutamate transport Type: Transport Location: Mitochondria, Cytosol KEGG ID: NA click to see details on this item	Not applicable	e4hgluName: L-erythro-4-Hydroxyglutamate Formula: C5H8NO5 Charge: -1 click to see details on this item[c]		e4hgluName: L-erythro-4-Hydroxyglutamate Formula: C5H8NO5 Charge: -1 click to see details on this item[m]	Not determined	Transport

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