Network Biomass WormPaths

PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal

Metabolite Overview

Abbreviation .....................................................	:	4h2oglt
Name .....................................................	:	4-Hydroxy-2-oxoglutarate, etc.(4R)-4-Hydroxy-2-oxoglutarate, (R)-2-Hydroxy-4-oxopentanedioate, D-4-Hydroxy-2-oxoglutarate
Model ID .....................................................	:	C05946
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C05946
Formula .....................................................	:	C5H4O6
Charge .....................................................	:	-2
Localization .....................................................	:	Mitochondria, Cytosol
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	4h2oglt
Other associations .....................................................	:	See reaction table below.
In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Proline metabolism (c,m)

iCEL1314

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RM05052Name: L-erythro-4-hydroxyglutamate:2-oxoglutarate aminotransferase Type: Regular Location: Mitochondria KEGG ID: R05052 click to see details on this item	2.6.1.1Name: aspartate transaminase Other names: glutamic-oxaloacetic transaminase, glutamic-aspartic transaminase, transaminase A, AAT, AspT, 2-oxoglutarate-glutamate aminotransferase, aspartate alpha-ketoglutarate transaminase, aspartate aminotransferase, aspartate-2-oxoglutarate transaminase, aspartic acid aminotransferase, aspartic aminotransferase, aspartyl aminotransferase, AST, glutamate-oxalacetate aminotransferase, glutamate-oxalate transaminase, glutamic-aspartic aminotransferase, glutamic-oxalacetic transaminase, glutamic oxalic transaminase, GOT (enzyme) [ambiguous], L-aspartate transaminase, L-aspartate-alpha-ketoglutarate transaminase, L-aspartate-2-ketoglutarate aminotransferase, L-aspartate-2-oxoglutarate aminotransferase, L-aspartate-2-oxoglutarate-transaminase, L-aspartic aminotransferase, oxaloacetate-aspartate aminotransferase, oxaloacetate transferase, aspartate:2-oxoglutarate aminotransferase, glutamate oxaloacetate transaminase click to see details on this item	[m] : akgName: 2-Oxoglutarate Formula: C5H4O5 Charge: -2 click to see details on this item + e4hgluName: L-erythro-4-Hydroxyglutamate Formula: C5H8NO5 Charge: -1 click to see details on this item		4h2ogltName: 4-Hydroxy-2-oxoglutarate Formula: C5H4O6 Charge: -2 click to see details on this item + glu-LName: L-Glutamate Formula: C5H8NO4 Charge: -1 click to see details on this item	got-2.1 | got-2.2	Proline metabolism
RC05052Name: L-erythro-4-hydroxyglutamate:2-oxoglutarate aminotransferase Type: Regular Location: Cytosol KEGG ID: R05052 click to see details on this item	2.6.1.1Name: aspartate transaminase Other names: glutamic-oxaloacetic transaminase, glutamic-aspartic transaminase, transaminase A, AAT, AspT, 2-oxoglutarate-glutamate aminotransferase, aspartate alpha-ketoglutarate transaminase, aspartate aminotransferase, aspartate-2-oxoglutarate transaminase, aspartic acid aminotransferase, aspartic aminotransferase, aspartyl aminotransferase, AST, glutamate-oxalacetate aminotransferase, glutamate-oxalate transaminase, glutamic-aspartic aminotransferase, glutamic-oxalacetic transaminase, glutamic oxalic transaminase, GOT (enzyme) [ambiguous], L-aspartate transaminase, L-aspartate-alpha-ketoglutarate transaminase, L-aspartate-2-ketoglutarate aminotransferase, L-aspartate-2-oxoglutarate aminotransferase, L-aspartate-2-oxoglutarate-transaminase, L-aspartic aminotransferase, oxaloacetate-aspartate aminotransferase, oxaloacetate transferase, aspartate:2-oxoglutarate aminotransferase, glutamate oxaloacetate transaminase click to see details on this item	[c] : akgName: 2-Oxoglutarate Formula: C5H4O5 Charge: -2 click to see details on this item + e4hgluName: L-erythro-4-Hydroxyglutamate Formula: C5H8NO5 Charge: -1 click to see details on this item		4h2ogltName: 4-Hydroxy-2-oxoglutarate Formula: C5H4O6 Charge: -2 click to see details on this item + glu-LName: L-Glutamate Formula: C5H8NO4 Charge: -1 click to see details on this item	got-1.2	Proline metabolism
RM00471Name: D-4-Hydroxy-2-oxoglutarate glyoxylate-lyase Type: Regular Location: Mitochondria KEGG ID: R00471 click to see details on this item	4.1.3.16Name: 4-hydroxy-2-oxoglutarate aldolase Other names: 2-oxo-4-hydroxyglutarate aldolase, hydroxyketoglutaric aldolase, 4-hydroxy-2-ketoglutaric aldolase, 2-keto-4-hydroxyglutaric aldolase, 4-hydroxy-2-ketoglutarate aldolase, 2-keto-4-hydroxyglutarate aldolase, 2-oxo-4-hydroxyglutaric aldolase, DL-4-hydroxy-2-ketoglutarate aldolase, hydroxyketoglutarate aldolase, 2-keto-4-hydroxybutyrate aldolase, 4-hydroxy-2-oxoglutarate glyoxylate-lyase, KHGA click to see details on this item	[m] : 4h2ogltName: 4-Hydroxy-2-oxoglutarate Formula: C5H4O6 Charge: -2 click to see details on this item		glxName: Glyoxylate Formula: C2H1O3 Charge: -1 click to see details on this item + pyrName: Pyruvate Formula: C3H3O3 Charge: -1 click to see details on this item	Unknown	Proline metabolism
RC00471Name: D-4-Hydroxy-2-oxoglutarate glyoxylate-lyase Type: Regular Location: Cytosol KEGG ID: R00471 click to see details on this item	4.1.3.16Name: 4-hydroxy-2-oxoglutarate aldolase Other names: 2-oxo-4-hydroxyglutarate aldolase, hydroxyketoglutaric aldolase, 4-hydroxy-2-ketoglutaric aldolase, 2-keto-4-hydroxyglutaric aldolase, 4-hydroxy-2-ketoglutarate aldolase, 2-keto-4-hydroxyglutarate aldolase, 2-oxo-4-hydroxyglutaric aldolase, DL-4-hydroxy-2-ketoglutarate aldolase, hydroxyketoglutarate aldolase, 2-keto-4-hydroxybutyrate aldolase, 4-hydroxy-2-oxoglutarate glyoxylate-lyase, KHGA click to see details on this item	[c] : 4h2ogltName: 4-Hydroxy-2-oxoglutarate Formula: C5H4O6 Charge: -2 click to see details on this item		glxName: Glyoxylate Formula: C2H1O3 Charge: -1 click to see details on this item + pyrName: Pyruvate Formula: C3H3O3 Charge: -1 click to see details on this item	Unknown	Proline metabolism
TCM1109Name: 4-Hydroxy-2-oxoglutarate transport Type: Transport Location: Mitochondria, Cytosol KEGG ID: NA click to see details on this item	Not applicable	4h2ogltName: 4-Hydroxy-2-oxoglutarate Formula: C5H4O6 Charge: -2 click to see details on this item[c]		4h2ogltName: 4-Hydroxy-2-oxoglutarate Formula: C5H4O6 Charge: -2 click to see details on this item[m]	Not determined	Transport

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