Network Biomass WormPaths

PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal

Metabolite Overview

Abbreviation .....................................................	:	mthgxl
Name .....................................................	:	Methylglyoxal, etc.Pyruvaldehyde, Pyruvic aldehyde, 2-Ketopropionaldehyde, 2-Oxopropanal
Model ID .....................................................	:	C00546
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C00546
Formula .....................................................	:	C3H4O2
Charge .....................................................	:	0
Localization .....................................................	:	Mitochondria, Cytosol, Extracellular
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	mthgxl
Other associations .....................................................	:	See reaction table below (9 reactions in total)
In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Methylglyoxal detoxification (c,m)

iCEL1314

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RC02529Name: aminoacetone:oxygen oxidoreductase (deaminating) Type: Regular Location: Cytosol KEGG ID: R02529 click to see details on this item	1.4.3.4Name: monoamine oxidase Other names: adrenalin oxidase, adrenaline oxidase, amine oxidase (ambiguous), amine oxidase (flavin-containing), amine:oxygen oxidoreductase (deaminating) (flavin-containing), epinephrine oxidase, MAO, MAO A, MAO B, MAO-A, MAO-B, monoamine oxidase A, monoamine oxidase B, monoamine:O2 oxidoreductase (deaminating), polyamine oxidase (ambiguous), serotonin deaminase, spermidine oxidase (ambiguous), spermine oxidase (ambiguous), tyraminase, tyramine oxidase click to see details on this item	[c] : aactName: Aminoacetone Formula: C3H8NO Charge: 1 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + o2Name: O2 Formula: O2 Charge: 0 click to see details on this item		mthgxlName: Methylglyoxal Formula: C3H4O2 Charge: 0 click to see details on this item + nh4Name: Ammonium Formula: H4N Charge: 1 click to see details on this item + h2o2Name: Hydrogen peroxide Formula: H2O2 Charge: 0 click to see details on this item	amx-2	Methylglyoxal detoxification
RM02529Name: aminoacetone:oxygen oxidoreductase(deaminating) Type: Regular Location: Mitochondria KEGG ID: R02529 click to see details on this item	1.4.3.4Name: monoamine oxidase Other names: adrenalin oxidase, adrenaline oxidase, amine oxidase (ambiguous), amine oxidase (flavin-containing), amine:oxygen oxidoreductase (deaminating) (flavin-containing), epinephrine oxidase, MAO, MAO A, MAO B, MAO-A, MAO-B, monoamine oxidase A, monoamine oxidase B, monoamine:O2 oxidoreductase (deaminating), polyamine oxidase (ambiguous), serotonin deaminase, spermidine oxidase (ambiguous), spermine oxidase (ambiguous), tyraminase, tyramine oxidase click to see details on this item	[m] : aactName: Aminoacetone Formula: C3H8NO Charge: 1 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item + o2Name: O2 Formula: O2 Charge: 0 click to see details on this item		mthgxlName: Methylglyoxal Formula: C3H4O2 Charge: 0 click to see details on this item + nh4Name: Ammonium Formula: H4N Charge: 1 click to see details on this item + h2o2Name: Hydrogen peroxide Formula: H2O2 Charge: 0 click to see details on this item	amx-2	Methylglyoxal detoxification
RC02531Name: Lactaldehyde:NAD+ 1-oxidoreductase Type: Regular Location: Cytosol KEGG ID: R02531 click to see details on this item	1.1.1.21Name: aldehyde reductase Other names: aldose reductase, polyol dehydrogenase (NADP+), ALR2, alditol:NADP+ oxidoreductase, alditol:NADP+ 1-oxidoreductase, NADPH-aldopentose reductase, NADPH-aldose reductase click to see details on this item	[c] : lald-DName: D-Lactaldehyde Formula: C3H6O2 Charge: 0 click to see details on this item + nadName: Nicotinamide adenine dinucleotide Formula: C21H26N7O14P2 Charge: -1 click to see details on this item		mthgxlName: Methylglyoxal Formula: C3H4O2 Charge: 0 click to see details on this item + nadhName: Nicotinamide adenine dinucleotide - reduced Formula: C21H27N7O14P2 Charge: -2 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item	Y39G8B.1	Methylglyoxal detoxification
RM02530Name: glyoxalase-1 Type: Regular Location: Mitochondria KEGG ID: R02530 click to see details on this item	4.4.1.5Name: lactoylglutathione lyase Other names: methylglyoxalase, aldoketomutase, ketone-aldehyde mutase, glyoxylase I, (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing) click to see details on this item	[m] : gthrdName: Reduced glutathione Formula: C10H16N3O6S Charge: -1 click to see details on this item + mthgxlName: Methylglyoxal Formula: C3H4O2 Charge: 0 click to see details on this item		lgt-SName: (R)-S-Lactoylglutathione Formula: C13H20N3O8S Charge: -1 click to see details on this item	glod-4	Methylglyoxal detoxification
RCC0131Name: methylglyoxal synthase Type: Regular Location: Cytosol KEGG ID: NA click to see details on this item	4.2.3.3Name: methylglyoxal synthase Other names: methylglyoxal synthetase, glycerone-phosphate phospho-lyase click to see details on this item	[c] : g3pName: Glyceraldehyde 3-phosphate Formula: C3H5O6P Charge: -2 click to see details on this item		mthgxlName: Methylglyoxal Formula: C3H4O2 Charge: 0 click to see details on this item + piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item	Unknown	Methylglyoxal detoxification
RC01016Name: methylglyoxal synthase Type: Regular Location: Cytosol KEGG ID: R01016 click to see details on this item	4.2.3.3Name: methylglyoxal synthase Other names: methylglyoxal synthetase, glycerone-phosphate phospho-lyase click to see details on this item	[c] : dhapName: Dihydroxyacetone phosphate Formula: C3H5O6P Charge: -2 click to see details on this item		mthgxlName: Methylglyoxal Formula: C3H4O2 Charge: 0 click to see details on this item + piName: Phosphate Formula: HO4P Charge: -2 click to see details on this item	Unknown	Methylglyoxal detoxification
TCM5060Name: methylglyoxal transport Type: Transport Location: Mitochondria, Cytosol KEGG ID: NA click to see details on this item	Not applicable	mthgxlName: Methylglyoxal Formula: C3H4O2 Charge: 0 click to see details on this item[c]		mthgxlName: Methylglyoxal Formula: C3H4O2 Charge: 0 click to see details on this item[m]	To be determined	Transport
TCE0660Name: Methylglyoxal transport Type: Transport Location: Extracellular, Cytosol KEGG ID: NA click to see details on this item	Not applicable	mthgxlName: Methylglyoxal Formula: C3H4O2 Charge: 0 click to see details on this item[c]		mthgxlName: Methylglyoxal Formula: C3H4O2 Charge: 0 click to see details on this item[e]	Not determined	Transport
EX00546Name: Methylglyoxal exchange Type: Exchange Location: Extracellular KEGG ID: NA click to see details on this item	Not applicable	mthgxlName: Methylglyoxal Formula: C3H4O2 Charge: 0 click to see details on this item[e]			Not applicable	Exchange with the environment

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