Network Biomass WormPaths

PEAPathway Enrichment Analysis

WormClustClustering- and enrichment-based association of genes with the metabolic network WPSWorm Perturb-Seq portal

Metabolite Overview

Abbreviation .....................................................	:	4abut
Name .....................................................	:	4-Aminobutanoate, etc.4-Aminobutanoic acid, 4-Aminobutyrate, 4-Aminobutyric acid, gamma-Aminobutyric acid, GABA
Model ID .....................................................	:	C00334
KEGG ID (?) Compounds in KEGG database that match this compound. .....................................................	:	C00334
Formula .....................................................	:	C4H9NO2
Charge .....................................................	:	0
Localization .....................................................	:	Mitochondria, Cytosol, Extracellular
BiGG matches (?) Compounds in BiGG database that match this compound. .....................................................	:	4abut
Other associations .....................................................	:	See reaction table below (7 reactions in total)
In WormPaths (?) Pathway maps where this metabolite is represented are listed here. Letters after map name indicate the compartments the metabolite is placed in the map: (c) Cytosol (m) Mitochondria (e) Extracellular space .....................................................	:	Arginine metabolism (c), Glutamate / glutamine metabolism (c,m)

iCEL1314

Reactions

ID

Enzyme

Reactants

Products

Genes (?) Multiple genes are separated by OR (I) or AND (&). I indicates that genes are redundant within the group (e.g. paralogs encoding the same enzyme). & indicates that genes are non-redundant within the group (e.g. genes encoding different subunits of the same enzyme). If there are multiple groups of genes, as in an enzyme complex with some enzymes associated with multiple genes, or in a case where the same enzyme is associated with different orthology groups with paralogs, each group with multiple genes is shown in parentheses.

Pathway

RM01648Name: 4-aminobutanoate:2-oxoglutarate aminotransferase Type: Regular Location: Mitochondria KEGG ID: R01648 click to see details on this item	2.6.1.19Name: 4-aminobutyrate---2-oxoglutarate transaminase Other names: beta-alanine-oxoglutarate transaminase, aminobutyrate aminotransferase (ambiguous), beta-alanine aminotransferase, beta-alanine-oxoglutarate aminotransferase, gamma-aminobutyrate aminotransaminase (ambiguous), gamma-aminobutyrate transaminase (ambiguous), gamma-aminobutyrate-alpha-ketoglutarate aminotransferase, gamma-aminobutyrate-alpha-ketoglutarate transaminase, gamma-aminobutyrate:alpha-oxoglutarate aminotransferase, gamma-aminobutyric acid aminotransferase (ambiguous), gamma-aminobutyric acid transaminase (ambiguous), gamma-aminobutyric acid-alpha-ketoglutarate transaminase, gamma-aminobutyric acid-alpha-ketoglutaric acid aminotransferase, gamma-aminobutyric acid-2-oxoglutarate transaminase, gamma-aminobutyric transaminase (ambiguous), 4-aminobutyrate aminotransferase (ambiguous), 4-aminobutyrate-2-ketoglutarate aminotransferase, 4-aminobutyrate-2-oxoglutarate aminotransferase, 4-aminobutyrate-2-oxoglutarate transaminase, 4-aminobutyric acid 2-ketoglutaric acid aminotransferase, 4-aminobutyric acid aminotransferase (ambiguous), aminobutyrate transaminase (ambiguous), GABA aminotransferase (ambiguous), GABA transaminase (ambiguous), GABA transferase, GABA-alpha-ketoglutarate aminotransferase, GABA-alpha-ketoglutarate transaminase, GABA-alpha-ketoglutaric acid transaminase, GABA-alpha-oxoglutarate aminotransferase, GABA-2-oxoglutarate aminotransferase, GABA-2-oxoglutarate transaminase, GABA-oxoglutarate aminotransferase, GABA-oxoglutarate transaminase, glutamate-succinic semialdehyde transaminase, GabT click to see details on this item	[m] : 4abutName: 4-Aminobutanoate Formula: C4H9NO2 Charge: 0 click to see details on this item + akgName: 2-Oxoglutarate Formula: C5H4O5 Charge: -2 click to see details on this item		glu-LName: L-Glutamate Formula: C5H8NO4 Charge: -1 click to see details on this item + sucsalName: Succinic semialdehyde Formula: C4H5O3 Charge: -1 click to see details on this item	gta-1	Glutamate / glutamine metabolism
RC00261Name: L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming) Type: Regular Location: Cytosol KEGG ID: R00261 click to see details on this item	4.1.1.15Name: glutamate decarboxylase Other names: L-glutamic acid decarboxylase, L-glutamic decarboxylase, cysteic acid decarboxylase, L-glutamate alpha-decarboxylase, aspartate 1-decarboxylase, aspartic alpha-decarboxylase, L-aspartate-alpha-decarboxylase, gamma-glutamate decarboxylase, L-glutamate 1-carboxy-lyase click to see details on this item	[c] : glu-LName: L-Glutamate Formula: C5H8NO4 Charge: -1 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item		4abutName: 4-Aminobutanoate Formula: C4H9NO2 Charge: 0 click to see details on this item + co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item	unc-25	Glutamate / glutamine metabolism
RM00261Name: L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming) Type: Regular Location: Mitochondria KEGG ID: R00261 click to see details on this item	4.1.1.15Name: glutamate decarboxylase Other names: L-glutamic acid decarboxylase, L-glutamic decarboxylase, cysteic acid decarboxylase, L-glutamate alpha-decarboxylase, aspartate 1-decarboxylase, aspartic alpha-decarboxylase, L-aspartate-alpha-decarboxylase, gamma-glutamate decarboxylase, L-glutamate 1-carboxy-lyase click to see details on this item	[m] : glu-LName: L-Glutamate Formula: C5H8NO4 Charge: -1 click to see details on this item + hName: H+ Formula: H Charge: 1 click to see details on this item		4abutName: 4-Aminobutanoate Formula: C4H9NO2 Charge: 0 click to see details on this item + co2Name: CO2 Formula: CO2 Charge: 0 click to see details on this item	unc-25	Glutamate / glutamine metabolism
RC01987Name: 4-acetamidobutanoate amidohydrolase Type: Regular Location: Cytosol KEGG ID: R01987 click to see details on this item	3.5.1.63Name: 4-acetamidobutyrate deacetylase click to see details on this item	[c] : 4aabutnName: 4-Acetamidobutanoate Formula: C6H10NO3 Charge: -1 click to see details on this item + h2oName: H2O Formula: H2O Charge: 0 click to see details on this item		4abutName: 4-Aminobutanoate Formula: C4H9NO2 Charge: 0 click to see details on this item + acName: Acetate Formula: C2H3O2 Charge: -1 click to see details on this item	Unknown	Arginine metabolism
TCM1286Name: 4-Aminobutanoate transport Type: Transport Location: Mitochondria, Cytosol KEGG ID: NA click to see details on this item	Not applicable	4abutName: 4-Aminobutanoate Formula: C4H9NO2 Charge: 0 click to see details on this item[c]		4abutName: 4-Aminobutanoate Formula: C4H9NO2 Charge: 0 click to see details on this item[m]	Not determined	Transport
TCE0719Name: 4-Aminobutanoate transport Type: Transport Location: Cytosol, Extracellular KEGG ID: NA click to see details on this item	Not applicable	4abutName: 4-Aminobutanoate Formula: C4H9NO2 Charge: 0 click to see details on this item[e]		4abutName: 4-Aminobutanoate Formula: C4H9NO2 Charge: 0 click to see details on this item[c]	Not determined	Transport
EX00334Name: 4-Aminobutanoate exchange Type: Exchange Location: Extracellular KEGG ID: NA click to see details on this item	Not applicable	4abutName: 4-Aminobutanoate Formula: C4H9NO2 Charge: 0 click to see details on this item[e]			Not applicable	Exchange with the environment

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